FOXP1 - Forkhead box protein P1 - human protein (Function)
 
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FOXP1 »  Forkhead box protein P1
 
Protein also known as:  Mac-1-regulated forkhead (MFH).
Gene name:  FOXP1
Entry whose protein(s) existence is based on evidence at protein level
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1 102 8
GENE REF ISO

Function

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Overview 
Transcriptional repressor (PubMed18347093). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed15286807, PubMed18799727, PubMed18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed24023716). Can negatively regulate androgen receptor signaling (PubMed18640093).  
9
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • RefGenome
GO biological process 
Chemokine (C-C motif) ligand 2 secretiondefinition[GO:0035926]  
1
  • UniProtKB
Endothelial cell activationdefinition[GO:0042118]  
1
  • UniProtKB
Interleukin-21 secretiondefinition[GO:0072619]  
1
  • Ortholog Curator
Macrophage activationdefinition[GO:0042116]  
1
  • UniProtKB
Monocyte activationdefinition[GO:0042117]  
1
  • UniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • UniProtKB
Negative regulation of B cell apoptotic processdefinition[GO:0002903]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Osteoclast developmentdefinition[GO:0036035]  
1
  • UniProtKB
Osteoclast differentiationdefinition[GO:0030316]  
1
  • UniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • UniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • UniProtKB
Regulation of defense response to bacteriumdefinition[GO:1900424]  
1
  • UniProtKB
Regulation of endothelial tube morphogenesisdefinition[GO:1901509]  
1
  • UniProtKB
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • UniProtKB
Regulation of interleukin-1 beta secretiondefinition[GO:0050706]  
1
  • UniProtKB
Regulation of interleukin-12 secretiondefinition[GO:2001182]  
1
  • UniProtKB
Regulation of macrophage colony-stimulating factor productiondefinition[GO:1901256]  
1
  • UniProtKB
Regulation of monocyte differentiationdefinition[GO:0045655]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • RefGenome
Regulation of tumor necrosis factor productiondefinition[GO:0032680]  
1
  • UniProtKB
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • UniProtKB
T follicular helper cell differentiationdefinition[GO:0061470]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • RefGenome
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXP1
GenomeRNAi: 27086
PRO: PR:Q9H334