FOXP1 - Forkhead box protein P1 - human protein (Function)
 
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FOXP1 »  Forkhead box protein P1
 
Gene name:  FOXP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IBARefGenome
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IBARefGenome
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IBARefGenome
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cardiac muscle cell differentiationdefinition[GO:0055007] silver  
  • IBARefGenome
Embryo developmentdefinition[GO:0009790] silver  
  • IBARefGenome
Immunoglobulin V(D)J recombinationdefinition[GO:0033152] silver  
  • IBARefGenome
Lung developmentdefinition[GO:0030324] silver  
  • IBARefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IBARefGenome
Positive regulation of immunoglobulin productiondefinition[GO:0002639] silver  
  • IBARefGenome
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IBARefGenome
Pre-B cell differentiationdefinition[GO:0002329] silver  
  • IBARefGenome
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IBARefGenome
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IBARefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXP1
GenomeRNAi: 27086
PRO: PR:Q9H334