TP63 - Tumor protein 63 - human protein (Function)
 
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TP63 »  Tumor protein 63  (p63)
 
Protein also known as:  Keratinocyte transcription factor KET.
Gene name:  TP63
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
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1 547 12
GENE REF ISO

Function

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Overview 
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.  
7
  • UniProtKB
Isoform  Iso 2   Activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.  
8
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
2
  • UniProtKB
  • RefGenome
Damaged DNA bindingdefinition[GO:0003684]  
1
  • RefGenome
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
P53 bindingdefinition[GO:0002039]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • RefGenome
Transcription factor binding transcription factor activitydefinition[GO:0000989] silver  
1
  • Ortholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212] silver  
1
  • InterPro 2 GO
WW domain bindingdefinition[GO:0050699]  
1
  • UniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Isoform  Iso 2   Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • RefGenome
Chromatin remodelingdefinition[GO:0006338] silver  
1
  • Ortholog Compara
Cloacal septationdefinition[GO:0060197] silver  
1
  • Ortholog Compara
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • RefGenome
Ectoderm and mesoderm interactiondefinition[GO:0007499] silver  
1
  • Ortholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Epidermal cell divisiondefinition[GO:0010481] silver  
1
  • Ortholog Compara
Epithelial cell developmentdefinition[GO:0002064] silver  
1
  • Ortholog Compara
Establishment of planar polaritydefinition[GO:0001736] silver  
1
  • Ortholog Compara
Establishment of skin barrierdefinition[GO:0061436]  
1
  • Ortholog Curator
Female genitalia morphogenesisdefinition[GO:0048807] silver  
1
  • Ortholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • RefGenome
Keratinocyte differentiationdefinition[GO:0030216] silver  
1
  • Ortholog Compara
Keratinocyte proliferationdefinition[GO:0043616] silver  
1
  • Ortholog Compara
Mitotic G1 DNA damage checkpointdefinition[GO:0031571]  
1
  • RefGenome
Multicellular organismal agingdefinition[GO:0010259] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Isoform  Iso 2   Negative regulation of cellular senescencedefinition[GO:2000773]  
1
  • UniProtKB
Negative regulation of keratinocyte differentiationdefinition[GO:0045617] silver  
1
  • Ortholog Compara
Negative regulation of mesoderm developmentdefinition[GO:2000381] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • RefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Notch signaling pathwaydefinition[GO:0007219]  
1
  • UniProtKB KW
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Polarized epithelial cell differentiationdefinition[GO:0030859] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
1
  • Ortholog Compara
Isoform  Iso 2   Positive regulation of cell cycle G1/S phase transitiondefinition[GO:1902808]  
1
  • UniProtKB
Positive regulation of fibroblast apoptotic processdefinition[GO:2000271]  
1
  • UniProtKB
Positive regulation of keratinocyte proliferationdefinition[GO:0010838] silver  
1
  • Ortholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
1
  • Ortholog Compara
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
1
  • UniProtKB
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • UniProtKB
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
1
  • Ortholog Compara
Prostatic bud formationdefinition[GO:0060513] silver  
1
  • Ortholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • UniProtKB
Proximal/distal pattern formationdefinition[GO:0009954] silver  
1
  • Ortholog Compara
Regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043281] silver  
1
  • Ortholog Compara
Regulation of epidermal cell divisiondefinition[GO:0010482]  
1
  • Ortholog Curator
Regulation of neuron apoptotic processdefinition[GO:0043523]  
1
  • RefGenome
Replicative cell agingdefinition[GO:0001302] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332]  
1
  • RefGenome
Response to X-raydefinition[GO:0010165]  
1
  • RefGenome
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Skin morphogenesisdefinition[GO:0043589] silver  
1
  • Ortholog Compara
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentdefinition[GO:0060529] silver  
1
  • Ortholog Compara
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
1
  • Ortholog Compara
Urinary bladder developmentdefinition[GO:0060157] silver  
1
  • Ortholog Compara
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TP63
GenomeRNAi: 8626
PRO: PR:Q9H3D4