TP63 - Tumor protein 63 - human protein (Function)
 
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TP63 »  Tumor protein 63  (p63)
 
Protein also known as:  Chronic ulcerative stomatitis protein (CUSP).
Gene name:  TP63
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
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1 505 12
GENE REF ISO

Function

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Overview 
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.  
7
  • CuratedUniProtKB
Isoform  Iso 2   Activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.  
7
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
  • IBARefGenome
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IBARefGenome
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
P53 bindingdefinition[GO:0002039] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IBARefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IBARefGenome
Transcription regulatory region DNA bindingdefinition[GO:0044212] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Cellular response to UVdefinition[GO:0034644] silver  
  • IBARefGenome
Chromatin remodelingdefinition[GO:0006338] silver  
  • IEAOrtholog Compara
Cloacal septationdefinition[GO:0060197] silver  
  • IEAOrtholog Compara
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978] silver  
  • IBARefGenome
Ectoderm and mesoderm interactiondefinition[GO:0007499] silver  
  • IEAOrtholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IEAOrtholog Compara
Epidermal cell divisiondefinition[GO:0010481] silver  
  • IEAOrtholog Compara
Epithelial cell developmentdefinition[GO:0002064] silver  
  • IEAOrtholog Compara
Establishment of planar polaritydefinition[GO:0001736] silver  
  • IEAOrtholog Compara
Establishment of skin barrierdefinition[GO:0061436]  
  • ISSOrtholog Curator
Female genitalia morphogenesisdefinition[GO:0048807] silver  
  • IEAOrtholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771] silver  
  • IBARefGenome
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IEAOrtholog Compara
Keratinocyte proliferationdefinition[GO:0043616] silver  
  • IEAOrtholog Compara
Mitotic G1 DNA damage checkpointdefinition[GO:0031571] silver  
  • IBARefGenome
Multicellular organismal agingdefinition[GO:0010259] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of keratinocyte differentiationdefinition[GO:0045617] silver  
  • IEAOrtholog Compara
Negative regulation of mesoderm developmentdefinition[GO:2000381] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IBARefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Notch signaling pathwaydefinition[GO:0007219]  
  • IEAUniProtKB KW
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Polarized epithelial cell differentiationdefinition[GO:0030859] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast apoptotic processdefinition[GO:2000271]  
1
  • IDAUniProtKB
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
1
  • IDAUniProtKB
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IDAUniProtKB
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Prostatic bud formationdefinition[GO:0060513] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IPIUniProtKB
Proximal/distal pattern formationdefinition[GO:0009954] silver  
  • IEAOrtholog Compara
Regulation of epidermal cell divisiondefinition[GO:0010482]  
  • ISSOrtholog Curator
Regulation of neuron apoptotic processdefinition[GO:0043523] silver  
  • IBARefGenome
Response to gamma radiationdefinition[GO:0010332] silver  
  • IBARefGenome
Response to X-raydefinition[GO:0010165] silver  
  • IBARefGenome
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IEAOrtholog Compara
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentdefinition[GO:0060529] silver  
  • IEAOrtholog Compara
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
  • IEAOrtholog Compara
Urinary bladder developmentdefinition[GO:0060157] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TP63
GenomeRNAi: 8626
PRO: PR:Q9H3D4