TP63 - Tumor protein 63 - human protein (Sequence)
 
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TP63 »  Tumor protein 63  (p63)
 
Protein also known as:  Chronic ulcerative stomatitis protein (CUSP).
Gene name:  TP63
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 505 12
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   680 aaMass: 76785 Da,  pI: 6.12
MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND FNFDMDARRN KQQRIKEEGE

Sequence

 show evidences
Domain 
The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.  
2
  • CuratedUniProtKB
PTM 
May be sumoylated (By similarity).  
  • CuratedUniProtKB
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.  
1
  • CuratedUniProtKB
Sequence caution 
The sequence AAF43486 differs from that shown. Reason: erroneous initiation.  
2
  • CuratedUniProtKB
The sequence AAF43487 differs from that shown. Reason: erroneous initiation.  
2
  • CuratedUniProtKB
The sequence AAF43488 differs from that shown. Reason: erroneous initiation.  
2
  • CuratedUniProtKB
The sequence AAF43489 differs from that shown. Reason: erroneous initiation.  
2
  • CuratedUniProtKB
The sequence AAF61624 differs from that shown. Reason: frameshift at position 26.  
2
  • CuratedUniProtKB
The sequence BAA32592 differs from that shown. Reason: frameshift at position 26.  
2
  • CuratedUniProtKB
The sequence BAA32593 differs from that shown. Reason: frameshift at position 26.  
2
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative promoter usage  definition   [KW-0877]
Alternative splicing  definition   [KW-0025]
PTM 
Isopeptide bond  definition   [KW-1017]
Ubl conjugation  definition   [KW-0832]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 1.10.150.50
Gene3D: 2.60.40.720
Gene3D: 4.10.170.10
InterPro: IPR011615 [ p53 DNA-bd ]
InterPro: IPR008967 [ p53-like TF DNA-bd ]
InterPro: IPR010991 [ p53 tetrameristn ]
InterPro: IPR002117 [ p53 tumour suppressor ]
InterPro: IPR012346 [ p53/RUNT-type TF DNA-bd ]
InterPro: IPR013761 [ SAM/pointed ]
InterPro: IPR011510 [ SAM 2 ]
InterPro: IPR001660 [ SAM ]
PANTHER: PTHR11447 [ PTHR11447 ]
Pfam: PF00870 [ P53 ]
Pfam: PF07710 [ P53 tetramer ]
Pfam: PF07647 [ SAM 2 ]
PRINTS: PR00386 [ P53SUPPRESSR ]
PROSITE: PS00348 [ P53 ]
SMART: SM00454 [ SAM ]
SUPFAM: SSF47769 [ SSF47769 ]
SUPFAM: SSF49417 [ SSF49417 ]
SUPFAM: SSF47719 [ SSF47719 ]
Genome annotation databases
Ensembl: Transcript: ENST00000264731;  Protein: ENSP00000264731;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000320472;  Protein: ENSP00000317510;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000354600;  Protein: ENSP00000346614;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000392461;  Protein: ENSP00000376254;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000392463;  Protein: ENSP00000376256;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000440651;  Protein: ENSP00000394337;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000392460;  Protein: ENSP00000376253;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000449992;  Protein: ENSP00000387839;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000418709;  Protein: ENSP00000407144;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000434928;  Protein: ENSP00000401661;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000456148;  Protein: ENSP00000389485;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000437221;  Protein: ENSP00000392488;  Gene: ENSG00000073282.
Ensembl: Transcript: ENST00000382063;  Protein: ENSP00000371495;  Gene: ENSG00000073282.
KEGG: hsa:8626
UCSC: uc003fsc.2
UCSC: uc010hzc.1
UCSC: uc003frx.2
UCSC: uc003fsd.2
UCSC: uc010hzd.1
UCSC: uc003fsb.2
UCSC: uc003frz.2
UCSC: uc003fry.2
Organism-specific databases
MGI: MGI:1330810 [ Trp63 ]
Other
ChiTaRS: TP63
EvolutionaryTrace: Q9H3D4
PTM databases
PhosphoSite: Q9H3D4
Phylogenomic databases
eggNOG: NOG80479
HOVERGEN: HBG005201
InParanoid: Q9H3D4
KO: K10149
OMA: QRNTLTP
OrthoDB: EOG7JQBNW
PhylomeDB: Q9H3D4
Sequence databases
CCDS: CCDS46980.1 [ Q9H3D4-6 ]
CCDS: CCDS46976.1 [ Q9H3D4-3 ]
CCDS: CCDS46977.1 [ Q9H3D4-5 ]
CCDS: CCDS46978.1 [ Q9H3D4-2 ]
CCDS: CCDS46979.1 [ Q9H3D4-4 ]
CCDS: CCDS3293.1 [ Q9H3D4-1 ]
EMBL: mRNA:  AF075429 . Translation:  AAC62634.1 .
EMBL: Genomic DNA:  AF124528 , AF124529 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124536 , AF124537 , AF124538 , AF124539 . Translation:  AAG45607.1 .
EMBL: mRNA:  AF075432 . Translation:  AAC62637.1 .
EMBL: Genomic DNA:  AY339663 . Translation:  AAQ63449.1 .
EMBL: Genomic DNA:  AF124530 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124536 , AF124537 , AF124539 . Translation:  AAG45611.1 .
EMBL: Genomic DNA:  AF116758 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116767 , AF116768 , AF116769 . Translation:  AAF43491.1 .
EMBL: mRNA:  BC039815 . Translation:  AAH39815.1 .
EMBL: mRNA:  AF061512 . Translation:  AAC24830.1 .
EMBL: Genomic DNA:  AY341144 . Translation:  AAQ63452.1 .
EMBL: mRNA:  AB016073 . Translation:  BAA32593.1 . Frameshift.
EMBL: mRNA:  AF075430 . Translation:  AAC62635.1 .
EMBL: mRNA:  AB010153 . Translation:  BAA32433.1 .
EMBL: mRNA:  AJ315499 . Translation:  CAC48053.1 .
EMBL: mRNA:  AF075428 . Translation:  AAC62633.1 .
EMBL: Genomic DNA:  AF124530 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124536 , AF124537 , AF124538 , AF124539 . Translation:  AAG45610.1 .
EMBL: Genomic DNA:  AF116756 , AF116757 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116770 . Translation:  AAF43486.1 . Different initiation.
EMBL: Genomic DNA:  AF116758 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116770 . Translation:  AAF43490.1 .
EMBL: Genomic DNA:  AF116756 , AF116757 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116769 . Translation:  AAF43489.1 . Different initiation.
EMBL: mRNA:  AB016072 . Translation:  BAA32592.1 . Frameshift.
EMBL: Genomic DNA:  AY341145 , AY342152 . Translation:  AAQ63448.1 .
EMBL: Genomic DNA:  AY339664 , AY341142 , AY341143 . Translation:  AAQ63450.1 .
EMBL: Genomic DNA:  AF116758 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116769 . Translation:  AAF43493.1 .
EMBL: Genomic DNA:  AF124528 , AF124529 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124540 . Translation:  AAG45609.1 .
EMBL: mRNA:  AF075433 . Translation:  AAC62638.1 .
EMBL: Genomic DNA:  AF124528 , AF124529 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124536 , AF124537 , AF124539 . Translation:  AAG45608.1 .
EMBL: mRNA:  AF091627 . Translation:  AAC43038.1 .
EMBL: mRNA:  AB042841 . Translation:  BAB20591.1 .
EMBL: Genomic DNA:  AF124530 , AF124531 , AF124532 , AF124533 , AF124534 , AF124535 , AF124540 . Translation:  AAG45612.1 .
EMBL: mRNA:  AF075431 . Translation:  AAC62636.1 .
EMBL: Genomic DNA:  AY342153 . Translation:  AAQ63453.1 .
EMBL: mRNA:  AF116771 . Translation:  AAF61624.1 . Frameshift.
EMBL: Genomic DNA:  AY341142 , AY341143 . Translation:  AAQ63451.1 .
EMBL: Genomic DNA:  AY342154 . Translation:  AAQ63454.1 .
EMBL: mRNA:  Y16961 . Translation:  CAA76562.1 .
EMBL: Genomic DNA:  AF116756 , AF116757 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116767 , AF116769 . Translation:  AAF43488.1 . Different initiation.
EMBL: Genomic DNA:  AF116758 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116767 , AF116769 . Translation:  AAF43492.1 .
EMBL: Genomic DNA:  AF116756 , AF116757 , AF116759 , AF116760 , AF116761 , AF116762 , AF116763 , AF116764 , AF116765 , AF116766 , AF116767 , AF116768 , AF116769 . Translation:  AAF43487.1 . Different initiation.
IPI: IPI00514298
IPI: IPI00514961
IPI: IPI00514807
IPI: IPI00301360
IPI: IPI00184272
IPI: IPI00514871
IPI: IPI00514665
IPI: IPI00513733
IPI: IPI00514384
IPI: IPI00514017
IPI: IPI00514155
IPI: IPI00479019
RefSeq: Protein:  NP_003713.3. Nucleotide sequence:  NM_003722.4.
RefSeq: Protein:  NP_001108453.1. Nucleotide sequence:  NM_001114981.1.
RefSeq: Protein:  XP_005247900.1. Nucleotide sequence:  XM_005247843.1.
RefSeq: Protein:  NP_001108452.1. Nucleotide sequence:  NM_001114980.1.
RefSeq: Protein:  NP_001108451.1. Nucleotide sequence:  NM_001114979.1.
RefSeq: Protein:  NP_001108450.1. Nucleotide sequence:  NM_001114978.1.
RefSeq: Protein:  NP_001108454.1. Nucleotide sequence:  NM_001114982.1.
UniProtKB: Q9H3D4 [ TP63 ]
Protocols and materials databases
DNASU: 8626