DPAGT1 - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase - human protein (Function)
 
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DPAGT1 »  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase   [ EC 2.7.8.15 ]
 
Protein also known as:  N-acetylglucosamine-1-phosphate transferase.
Gene name:  DPAGT1
Family name: Glycosyltransferase 4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.  
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  • UniProtKB
GO molecular function 
Phospho-N-acetylmuramoyl-pentapeptide-transferase activitydefinition[GO:0008963] silver  
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  • InterPro 2 GO
Transferase activity, transferring glycosyl groupsdefinition[GO:0016757]  
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  • UniProtKB KW
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activitydefinition[GO:0003975]  
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  • UniProtKB
GO biological process 
Dolichol biosynthetic processdefinition[GO:0019408]  
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  • UniProtKB
Polysaccharide biosynthetic processdefinition[GO:0000271]  
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  • RefGenome
Protein N-linked glycosylationdefinition[GO:0006487]  
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  • UniProtKB
Protein oligomerizationdefinition[GO:0051259]  
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  • Ortholog Curator
UDP-N-acetylglucosamine metabolic processdefinition[GO:0006047]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.8.15: UDP-N-acetyl-D-glucosamine + dolichyl phosphate UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.  
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  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1798  
N-Glycan biosynthesis  hsa00510+1798  
According to Reactome, this protein belongs to the following pathways:
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein  REACT_22433  
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2  REACT_268849  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DPAGT1
GenomeRNAi: 1798
PRO: PR:Q9H3H5