ATXN3L - Putative ataxin-3-like protein - human protein (Function)
 
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ATXN3L »  Putative ataxin-3-like protein   [ EC 3.4.19.12 ]
 
Protein also known as:  Machado-Joseph disease protein 1-like.
Gene name:  ATXN3L
Entry whose protein(s) existence is uncertain. Could be the product of a pseudogene. Suggested by the absence of intron.
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GENE REF ISO

Function

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Overview 
Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).  
  • CuratedUniProtKB
GO molecular function 
Omega peptidase activitydefinition[GO:0008242] silver  
  • IEAInterPro 2 GO
RNA polymerase II regulatory region DNA bindingdefinition[GO:0001012] silver  
  • IEAOrtholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
  • IEAOrtholog Compara
Ubiquitin thiolesterase activitydefinition[GO:0004221] silver  
  • IEAOrtholog Compara
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IDAUniProtKB
GO biological process 
Cellular response to heatdefinition[GO:0034605] silver  
  • IEAOrtholog Compara
Cellular response to misfolded proteindefinition[GO:0071218] silver  
  • IEAOrtholog Compara
Exploration behaviordefinition[GO:0035640] silver  
  • IEAOrtholog Compara
Histone H3 deacetylationdefinition[GO:0070932] silver  
  • IEAOrtholog Compara
Misfolded or incompletely synthesized protein catabolic processdefinition[GO:0006515] silver  
  • IEAOrtholog Compara
Monoubiquitinated protein deubiquitinationdefinition[GO:0035520] silver  
  • IEAOrtholog Compara
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161] silver  
  • IEAOrtholog Compara
Protein deubiquitinationdefinition[GO:0016579]  
1
  • IDAUniProtKB
Regulation of cell-substrate adhesiondefinition[GO:0010810] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+92552  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 92552