HIPK3 - Homeodomain-interacting protein kinase 3 - human protein (Function)
 
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HIPK3 »  Homeodomain-interacting protein kinase 3   [ EC 2.7.11.1 ]
 
Protein also known as:  Androgen receptor-interacting nuclear protein kinase (ANPK).
Gene name:  HIPK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • ISSUniProtKB
  • IDAMGI
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
mRNA transcriptiondefinition[GO:0009299]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of JUN kinase activitydefinition[GO:0043508]  
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • ISSUniProtKB
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • ISSUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HIPK3
GenomeRNAi: 10114
PRO: PR:Q9H422
Chemistry
GuidetoPHARMACOLOGY: 2035