FZD8 - Frizzled-8 - human protein (Function)
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FZD8 »  Frizzled-8  (Fz-8)
Gene name:  FZD8
Entry whose protein(s) existence is based on evidence at protein level
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Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
  • IPIUniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
  • TASUniProtKB
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147] silver  
  • IBARefGenome
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IBARefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IBARefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IBARefGenome
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8325  
HTLV-I infection  hsa05166+8325  
Melanogenesis  hsa04916+8325  
Pathways in cancer  hsa05200+8325  
Wnt signaling pathway  hsa04310+8325  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
regulation of FZD by ubiquitination  REACT_200716  


Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: FZD8
GenomeRNAi: 8325
PRO: PR:Q9H461