SENP3 - Sentrin-specific protease 3 - human protein (Function)
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SENP3 »  Sentrin-specific protease 3   [ EC ]
Protein also known as:  Sentrin/SUMO-specific protease SENP3.
Gene name:  SENP3
Family name: Peptidase C48
Entry whose protein(s) existence is based on evidence at protein level
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Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Ubiquitin-specific protease activitydefinition[GO:0004843] silver  
  • IEAOrtholog Compara
GO biological process 
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  
  • CuratedUniProtKB
It is regulated in the following manner
On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm.  
  • CuratedUniProtKB
More information is available from:


Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: SENP3
GenomeRNAi: 26168