DCTPP1 - dCTP pyrophosphatase 1 - human protein (Function)
 
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Protein
Gene
References

 
DCTPP1 »  dCTP pyrophosphatase 1   [ EC 3.6.1.12 ]
 
Protein also known as:  XTP3-transactivated gene A protein.
Gene name:  DCTPP1
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).  
  • CuratedUniProtKB
GO molecular function 
dCTP diphosphatase activitydefinition[GO:0047840]  
  • IEAEC 2 GO
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
Nucleoside-triphosphate diphosphatase activitydefinition[GO:0047429]  
  • ISSOrtholog Curator
Pyrimidine deoxyribonucleotide bindingdefinition[GO:0032556] silver  
  • IEAOrtholog Compara
GO biological process 
Nucleoside triphosphate catabolic processdefinition[GO:0009143]  
  • ISSOrtholog Curator
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.12: dCTP + H(2)O dCMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium. Probably binds two or three magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links