KAT8 - Histone acetyltransferase KAT8 - human protein (Function)
 
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KAT8 »  Histone acetyltransferase KAT8   [ EC 2.3.1.48 ]
 
Protein also known as:  MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 (MYST-1).
Gene name:  KAT8
Family name: MYST (SAS/MOZ)
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.  
5
  • CuratedUniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
1
  • IDAUniProtKB
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K16 specific)definition[GO:0046972]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K5 specific)definition[GO:0043995]  
1
  • IDAUniProtKB
Contributes to histone acetyltransferase activity (H4-K8 specific)definition[GO:0043996]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Methylated histone residue bindingdefinition[GO:0035064]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • IDAUniProtKB
GO biological process 
Histone acetylationdefinition[GO:0016573]  
1
  • IDAUniProtKB
Histone H4-K16 acetylationdefinition[GO:0043984]  
2
  • IDAUniProtKB
Histone H4-K5 acetylationdefinition[GO:0043981]  
1
  • IDAUniProtKB
Histone H4-K8 acetylationdefinition[GO:0043982]  
1
  • IDAUniProtKB
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IMPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
3
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Chromatin organization  REACT_172623  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Chromatin regulator  definition   [KW-0156]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYST1
GenomeRNAi: 84148
PRO: PR:Q9H7Z6