KAT8 - Histone acetyltransferase KAT8 - human protein (Function)
 
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KAT8 »  Histone acetyltransferase KAT8   [ EC 2.3.1.48 ]
 
Protein also known as:  MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 (MYST-1).
Gene name:  KAT8
Family name: MYST (SAS/MOZ)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.  
7
  • UniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
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  • UniProtKB
Enzyme bindingdefinition[GO:0019899] silver  
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  • Ortholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
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  • UniProtKB
Contributes to histone acetyltransferase activity (H4-K16 specific)definition[GO:0046972]  
1
  • UniProtKB
Contributes to histone acetyltransferase activity (H4-K5 specific)definition[GO:0043995]  
1
  • UniProtKB
Contributes to histone acetyltransferase activity (H4-K8 specific)definition[GO:0043996]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Methylated histone bindingdefinition[GO:0035064]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • UniProtKB
GO biological process 
Histone acetylationdefinition[GO:0016573]  
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  • UniProtKB
Histone H4-K16 acetylationdefinition[GO:0043984]  
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  • UniProtKB
Histone H4-K5 acetylationdefinition[GO:0043981]  
1
  • UniProtKB
Histone H4-K8 acetylationdefinition[GO:0043982]  
1
  • UniProtKB
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
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  • UniProtKB
Regulation of autophagydefinition[GO:0010506]  
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  • MGI
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
5
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_264245  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Chromatin regulator  definition   [KW-0156]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MYST1
GenomeRNAi: 84148
PRO: PR:Q9H7Z6
Chemistry
GuidetoPHARMACOLOGY: 2668