PTGES2 - Prostaglandin E synthase 2 - human protein (Function)
 
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Protein
Gene
References

 
PTGES2 »  Prostaglandin E synthase 2
 
Protein also known as:  Microsomal prostaglandin E synthase 2 (mPGES-2). Cleaved into:  Prostaglandin E synthase 2 truncated form.
Gene name:  PTGES2
Family name: GST
This protein has been shown to exist at protein level
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GENE REF ISO

Function

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Overview 
Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Electron carrier activitydefinition[GO:0009055] silver  
  • IEAInterPro 2 GO
Prostaglandin-E synthase activitydefinition[GO:0050220]  
  • IEAEC 2 GO
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Positive regulation of transcription, DNA-dependentdefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Prostaglandin biosynthetic processdefinition[GO:0001516]  
  • IEAUniPathway
Secretiondefinition[GO:0046903] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.99.3: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.  
  • CuratedUniProtKB
It requires the following cofactor
Dihydrolipoic acid.  
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  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+80142  
Metabolic pathways  hsa01100+80142  
According to Pathway Interaction DB, this protein belongs to the following pathway:
IFN-gamma pathway  ifngpathway  
 

Keywords

Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Prostaglandin biosynthesis  definition   [KW-0643]
Prostaglandin metabolism  definition   [KW-0644]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]