PTGES2 - Prostaglandin E synthase 2 - human protein (Function)
 
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PTGES2 »  Prostaglandin E synthase 2   [ EC 5.3.99.3EC 4.1.2.- ]
 
Protein also known as:  Microsomal prostaglandin E synthase 2 (mPGES-2). Cleaved into:  Prostaglandin E synthase 2 truncated form.
Gene name:  PTGES2
Family name: GST
Entry whose protein(s) existence is based on evidence at protein level
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1 16 1
GENE REF ISO

Function

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Overview 
Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme (mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable prostaglandin E2 (PGE2) form (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Electron carrier activitydefinition[GO:0009055] silver  
  • IEAInterPro 2 GO
Glutathione bindingdefinition[GO:0043295]  
  • ISSOrtholog Curator
Heme bindingdefinition[GO:0020037]  
  • ISSOrtholog Curator
Lyase activitydefinition[GO:0016829]  
  • ISSOrtholog Curator
Prostaglandin-E synthase activitydefinition[GO:0050220]  
  • IEAEC 2 GO
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Prostaglandin biosynthetic processdefinition[GO:0001516]  
  • IEAUniPathway
Secretiondefinition[GO:0046903] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 5.3.99.3: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.  
  • CuratedUniProtKB
EC 4.1.2.-: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate malonaldehyde + (5Z,8E,10E)-(12S)-hydroxyheptadeca-5,8,10-trienoate.  
  • CuratedUniProtKB
It requires the following cofactors
Dihydrolipoic acid; required for isomerase activity.  
1
  • CuratedUniProtKB
Glutathione (GSH). Required for lyase activity (By similarity).  
1
  • CuratedUniProtKB
Heme. Required for lyase activity (By similarity).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+80142  
Metabolic pathways  hsa01100+80142  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Prostaglandin biosynthesis  definition   [KW-0643]
Prostaglandin metabolism  definition   [KW-0644]
Molecular function 
Isomerase  definition   [KW-0413]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTGES2
GenomeRNAi: 80142
PRO: PR:Q9H7Z7