ACAD9 - Acyl-CoA dehydrogenase family member 9, mitochondrial - human protein (Function)
 
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ACAD9 »  Acyl-CoA dehydrogenase family member 9, mitochondrial   [ EC 1.3.99.- ]  (ACAD-9)
 
Gene name:  ACAD9
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for mitochondrial complex I assembly (PubMed20816094, PubMed24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed20816094, PubMed24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).  
3
  • UniProtKB
GO molecular function 
Acyl-CoA dehydrogenase activitydefinition[GO:0003995]  
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  • RefGenome
Electron carrier activitydefinition[GO:0009055]  
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  • RefGenome
Fatty-acyl-CoA bindingdefinition[GO:0000062]  
1
  • RefGenome
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • RefGenome
Oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptordefinition[GO:0052890]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Fatty acid beta-oxidation using acyl-CoA dehydrogenasedefinition[GO:0033539]  
1
  • RefGenome
Lipid homeostasisdefinition[GO:0055088]  
1
  • RefGenome
Mitochondrial respiratory chain complex I assemblydefinition[GO:0032981]  
1
  • UniProtKB
Enzymatic activity 
It requires the following cofactor
 FAD  
1
  • UniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9H845
Other
GeneWiki: ACAD9
GenomeRNAi: 28976
PRO: PR:Q9H845