AKTIP - AKT-interacting protein - human protein (Function)
 
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AKTIP »  AKT-interacting protein
 
Protein also known as:  Fused toes protein homolog.
Gene name:  AKTIP
Entry whose protein(s) existence is based on evidence at protein level
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1 17 2
GENE REF ISO

Function

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Overview 
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Ubiquitin protein ligase activitydefinition[GO:0061630]  
1
  • RefGenome
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • RefGenome
Contradiction  Ubiquitin-like protein transferase activitydefinition[GO:0019787]  
2
  • UniProtKB
  • RefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Early endosome to late endosome transportdefinition[GO:0045022]  
1
  • UniProtKB
Endosome organizationdefinition[GO:0007032]  
1
  • UniProtKB
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • UniProtKB
Lysosome organizationdefinition[GO:0007040]  
1
  • UniProtKB
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • MGI
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • MGI
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
Protein ubiquitinationdefinition[GO:0016567]  
1
  • RefGenome
Caution 
Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.  
1
  • UniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AKTIP
GenomeRNAi: 64400
PRO: PR:Q9H8T0