MED20 - Mediator of RNA polymerase II transcription subunit 20 - human protein (Function)
 
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MED20 »  Mediator of RNA polymerase II transcription subunit 20
 
Protein also known as:  TRF-proximal protein homolog.
Gene name:  MED20
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 14 1
GENE REF ISO

Function

 show evidences
Overview 
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  
  • CuratedUniProtKB
GO molecular function 
DNA-directed RNA polymerase activitydefinition[GO:0003899]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
RNA polymerase II transcription cofactor activitydefinition[GO:0001104] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
  • IEAInterPro 2 GO
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Generic Transcription Pathway  REACT_12627  
PPARA activates gene expression  REACT_116145  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9477
PRO: PR:Q9H944