NHEJ1 - Non-homologous end-joining factor 1 - human protein (Function)
 
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NHEJ1 »  Non-homologous end-joining factor 1
 
Protein also known as:  Protein cernunnos.
Gene name:  NHEJ1
Family name: XLF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary.  
4
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
GO biological process 
B cell differentiationdefinition[GO:0030183]  
1
  • UniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • UniProtKB
DNA recombinationdefinition[GO:0006310] silver  
1
  • InterPro 2 GO
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303]  
2
  • UniProtKB
Positive regulation of ligase activitydefinition[GO:0051351]  
1
  • UniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • UniProtKB
T cell differentiationdefinition[GO:0030217]  
1
  • UniProtKB
Note 
Was named 'Cernunnos' after the enigmatic Celtic god of hunting, the underworld and fertility.  
1
  • UniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XLF_(protein)
GenomeRNAi: 79840
PRO: PR:Q9H9Q4