NHEJ1 - Non-homologous end-joining factor 1 - human protein (Function)
 
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Protein
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References

 
NHEJ1 »  Non-homologous end-joining factor 1
 
Protein also known as:  Protein cernunnos.
Gene name:  NHEJ1
Family name: XLF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 2
GENE REF ISO

Function

 show evidences
Overview 
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary.  
3
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
B cell differentiationdefinition[GO:0030183]  
1
  • IMPUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • NASUniProtKB
DNA recombinationdefinition[GO:0006310] silver  
  • IEAInterPro 2 GO
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303]  
2
  • IMPUniProtKB
Positive regulation of ligase activitydefinition[GO:0051351]  
1
  • NASUniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • IDAUniProtKB
T cell differentiationdefinition[GO:0030217]  
1
  • IMPUniProtKB
Note 
Was named 'Cernunnos' after the enigmatic Celtic god of hunting, the underworld and fertility.  
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XLF_(protein)
GenomeRNAi: 79840
PRO: PR:Q9H9Q4