ELP3 - Elongator complex protein 3 - human protein (Function)
 
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ELP3 »  Elongator complex protein 3   [ EC 2.3.1.48 ]
 
Gene name:  ELP3
Family name: ELP3
Entry whose protein(s) existence is based on evidence at protein level
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1 32 4
GENE REF ISO

Function

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Overview 
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).  
7
  • UniProtKB
GO molecular function 
H3 histone acetyltransferase activitydefinition[GO:0010484]  
1
  • BHF-UCL
H4 histone acetyltransferase activitydefinition[GO:0010485]  
1
  • BHF-UCL
Iron-sulfur cluster bindingdefinition[GO:0051536]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Phosphorylase kinase regulator activitydefinition[GO:0008607]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • HGNC
Contributes to RNA polymerase II core bindingdefinition[GO:0000993]  
1
  • BHF-UCL
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
1
  • Ortholog Curator
Histone H3 acetylationdefinition[GO:0043966]  
1
  • BHF-UCL
Histone H4 acetylationdefinition[GO:0043967]  
1
  • BHF-UCL
Neuron migrationdefinition[GO:0001764]  
1
  • Ortholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • Ortholog Curator
Regulation of protein kinase activitydefinition[GO:0045859]  
1
  • GOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
2
  • UniProtKB
  • HGNC
Transcription elongation from RNA polymerase II promoterdefinition[GO:0006368]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
1
  • UniProtKB
It requires the following cofactor
 [4Fe-4S] cluster : Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_172610  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ELP3
GenomeRNAi: 55140
PRO: PR:Q9H9T3