ELP3 - Elongator complex protein 3 - human protein (Function)
 
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ELP3 »  Elongator complex protein 3   [ EC 2.3.1.48 ]
 
Gene name:  ELP3
Family name: ELP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 4
GENE REF ISO

Function

 show evidences
Overview 
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration.  
4
  • CuratedUniProtKB
GO molecular function 
Contributes to DNA bindingdefinition[GO:0003677]  
1
  • IDAHGNC
Histone acetyltransferase activitydefinition[GO:0004402]  
  • IEAEC 2 GO
Iron-sulfur cluster bindingdefinition[GO:0051536]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphorylase kinase regulator activitydefinition[GO:0008607]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Histone acetylationdefinition[GO:0016573]  
  • IEAEC 2 GO
Positive regulation of cell migrationdefinition[GO:0030335]  
  • ISSOrtholog Curator
Regulation of protein kinase activitydefinition[GO:0045859]  
1
  • IDAGOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
2
  • IDAUniProtKB
  • TASHGNC
Transcription elongation from RNA polymerase II promoterdefinition[GO:0006368]  
1
  • IDAHGNC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_172610  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ELP3
GenomeRNAi: 55140
PRO: PR:Q9H9T3