SLC28A3 - Solute carrier family 28 member 3 - human protein (Function)
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SLC28A3 »  Solute carrier family 28 member 3
Protein also known as:  Concentrative Na(+)-nucleoside cotransporter 3 (CNT 3).
Gene name:  SLC28A3
Entry whose protein(s) existence is based on evidence at protein level
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Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the concentrative nucleoside transporter (cnt) family  2.A.41.2.8  
GO molecular function 
Nucleoside bindingdefinition[GO:0001882] silver  
  • IEAInterPro 2 GO
Purine-specific nucleoside:sodium symporter activitydefinition[GO:0015390] silver  
  • IEAOrtholog Compara
Pyrimidine- and adenine-specific:sodium symporter activitydefinition[GO:0015389] silver  
  • IEAOrtholog Compara
GO biological process 
Purine nucleobase transportdefinition[GO:0006863]  
  • IEAOrtholog Compara
Purine nucleoside transmembrane transportdefinition[GO:0015860] silver  
  • IEAOrtholog Compara
Pyrimidine nucleobase transportdefinition[GO:0015855]  
  • IEAOrtholog Compara
Pyrimidine nucleoside transportdefinition[GO:0015864] silver  
  • IEAOrtholog Compara
Pyrimidine-containing compound transmembrane transportdefinition[GO:0072531]  
  • IEAOrtholog Compara
According to Reactome, this protein belongs to the following pathway:
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane  REACT_1206  

Biophysicochemical properties

Kinetic parameters
KM 43 uM for guanosine
KM 15.1 uM for adenosine
KM 15.4 uM for cytidine
KM 52.5 uM for inosine
KM 21.2 uM for thymidine
KM 21.6 uM for uridine
Vmax 25.8 pmol/min/mg enzyme for uridine uptake
Vmax 51.4 pmol/min/mg enzyme for guanosine uptake
Vmax 30.4 pmol/min/mg enzyme for adenosine uptake
Vmax 32.8 pmol/min/mg enzyme for cytidine uptake
Vmax 24.2 pmol/min/mg enzyme for thymidine uptake
Vmax 44.8 pmol/min/mg enzyme for inosine uptake


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 64078