UGT1A7 - UDP-glucuronosyltransferase 1-7 - human protein (Function)
 
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UGT1A7 »  UDP-glucuronosyltransferase 1-7   [ EC 2.4.1.17 ]  (UGT1.7)
 
Protein also known as:  UDP-glucuronosyltransferase 1A7.
Gene name:  UGT1A7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.  
1
  • UniProtKB
Isoform  Iso 2   Lacks transferase activity but acts as a negative regulator of isoform 1.  
2
  • UniProtKB
GO molecular function 
Isoform  Iso 1   Drug bindingdefinition[GO:0008144]  
1
  • BHF-UCL
Isoform  Iso 2   Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
Enzyme inhibitor activitydefinition[GO:0004857]  
2
  • BHF-UCL
Isoform  Iso 1 but not isoform  Iso 2   Glucuronosyltransferase activitydefinition[GO:0015020]  
7
  • BHF-UCL
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • BHF-UCL
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • BHF-UCL
Retinoic acid bindingdefinition[GO:0001972]  
1
  • BHF-UCL
GO biological process 
Cellular glucuronidationdefinition[GO:0052695]  
2
  • BHF-UCL
  • UniProtKB
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • RefGenome
Coumarin metabolic processdefinition[GO:0009804]  
1
  • BHF-UCL
Isoform  Iso 1 but not isoform  Iso 2   Drug metabolic processdefinition[GO:0017144]  
2
  • BHF-UCL
Excretiondefinition[GO:0007588]  
1
  • BHF-UCL
Isoform  Iso 1   Fatty acid metabolic processdefinition[GO:0006631]  
1
  • BHF-UCL
Flavone metabolic processdefinition[GO:0051552]  
1
  • BHF-UCL
Flavonoid biosynthetic processdefinition[GO:0009813]  
1
  • RefGenome
Flavonoid glucuronidationdefinition[GO:0052696]  
1
  • BHF-UCL
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • GOC
Isoform  Iso 2   Negative regulation of cellular glucuronidationdefinition[GO:2001030]  
1
  • UniProtKB
Isoform  Iso 2   Negative regulation of fatty acid metabolic processdefinition[GO:0045922]  
1
  • BHF-UCL
Isoform  Iso 2   Negative regulation of transferase activitydefinition[GO:0051348]  
1
  • BHF-UCL
Retinoic acid metabolic processdefinition[GO:0042573]  
1
  • BHF-UCL
Xenobiotic glucuronidationdefinition[GO:0052697]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.17: UDP-glucuronate + acceptor UDP + acceptor beta-D-glucuronoside.  
3
  • UniProtKB
EC 2.4.1.17: UDP-glucuronate + acceptor UDP + acceptor beta-D-glucuronoside.  
3
  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 1  GT1  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Ascorbate and aldarate metabolism  hsa00053+54577  
Drug metabolism - cytochrome P450  hsa00982+54577  
Drug metabolism - other enzymes  hsa00983+54577  
Metabolic pathways  hsa01100+54577  
Metabolism of xenobiotics by cytochrome P450  hsa00980+54577  
Other types of O-glycan biosynthesis  hsa00514+54577  
Pentose and glucuronate interconversions  hsa00040+54577  
Porphyrin and chlorophyll metabolism  hsa00860+54577  
Retinol metabolism  hsa00830+54577  
Starch and sucrose metabolism  hsa00500+54577  
Steroid hormone biosynthesis  hsa00140+54577  
According to Reactome, this protein belongs to the following pathway:
Glucuronidation  REACT_6784  
Note 
The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.  
1
  • UniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9HAW7
Other
GeneWiki: UGT1A7_(gene)
GenomeRNAi: 54577
PRO: PR:Q9HAW7