UGT1A7 - UDP-glucuronosyltransferase 1-7 - human protein (Function)
 
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UGT1A7 »  UDP-glucuronosyltransferase 1-7   [ EC 2.4.1.17 ]  (UGT1*7)
 
Protein also known as:  UDP-glucuronosyltransferase 1-G (UGT1G).
Gene name:  UGT1A7
Entry whose protein(s) existence is based on evidence at protein level
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1 43 1
GENE REF ISO

Function

 show evidences
Overview 
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.  
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IDABHF-UCL
Enzyme inhibitor activitydefinition[GO:0004857]  
2
  • IDABHF-UCL
Glucuronosyltransferase activitydefinition[GO:0015020]  
4
  • IDABHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Protein kinase C bindingdefinition[GO:0005080]  
1
  • IPIBHF-UCL
Retinoic acid bindingdefinition[GO:0001972]  
1
  • IDABHF-UCL
GO biological process 
Coumarin metabolic processdefinition[GO:0009804]  
1
  • ICBHF-UCL
Drug metabolic processdefinition[GO:0017144]  
2
  • IDABHF-UCL
Excretiondefinition[GO:0007588]  
1
  • ICBHF-UCL
Flavone metabolic processdefinition[GO:0051552]  
1
  • ICBHF-UCL
Flavonoid glucuronidationdefinition[GO:0052696]  
1
  • IDABHF-UCL
Negative regulation of catalytic activitydefinition[GO:0043086]  
2
  • IDAGOC
Negative regulation of fatty acid metabolic processdefinition[GO:0045922]  
1
  • IDABHF-UCL
Regulation of catalytic activitydefinition[GO:0050790]  
2
  • IDAGOC
Retinoic acid metabolic processdefinition[GO:0042573]  
1
  • ICBHF-UCL
Xenobiotic glucuronidationdefinition[GO:0052697]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.17: UDP-glucuronate + acceptor UDP + acceptor beta-D-glucuronoside.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 1  GT1  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Ascorbate and aldarate metabolism  hsa00053+54577  
Drug metabolism - cytochrome P450  hsa00982+54577  
Drug metabolism - other enzymes  hsa00983+54577  
Metabolic pathways  hsa01100+54577  
Metabolism of xenobiotics by cytochrome P450  hsa00980+54577  
Other types of O-glycan biosynthesis  hsa00514+54577  
Pentose and glucuronate interconversions  hsa00040+54577  
Porphyrin and chlorophyll metabolism  hsa00860+54577  
Retinol metabolism  hsa00830+54577  
Starch and sucrose metabolism  hsa00500+54577  
Steroid hormone biosynthesis  hsa00140+54577  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9HAW7
Other
GeneWiki: UGT1A7_(gene)
GenomeRNAi: 54577
PRO: PR:Q9HAW7