PRDM16 - PR domain zinc finger protein 16 - human protein (Function)
 
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PRDM16 »  PR domain zinc finger protein 16
 
Protein also known as:  PR domain-containing protein 16.
Gene name:  PRDM16
Entry whose protein(s) existence is based on evidence at protein level
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1 54 4
GENE REF ISO

Function

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Overview 
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling.  
3
  • CuratedUniProtKB
Isoform  Iso 4   May regulate granulocytes differentiation.  
3
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Isoform  Iso 4   Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
SMAD bindingdefinition[GO:0046332] silver  
  • IEAOrtholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
  • ISSOrtholog Curator
GO biological process 
Brown fat cell differentiationdefinition[GO:0050873]  
  • ISSOrtholog Curator
Isoform  Iso 4   Negative regulation of granulocyte differentiationdefinition[GO:0030853]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
2
  • IMPUniProtKB
Neurogenesisdefinition[GO:0022008] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of cellular respirationdefinition[GO:0043457]  
  • ISSOrtholog Curator
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Tongue developmentdefinition[GO:0043586] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
White fat cell differentiationdefinition[GO:0050872] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PRDM16
GenomeRNAi: 63976
PRO: PR:Q9HAZ2