TRPV4 - Transient receptor potential cation channel subfamily V member 4 - human protein (Function)
 
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References

 
TRPV4 »  Transient receptor potential cation channel subfamily V member 4  (TrpV4)
 
Protein also known as:  Vanilloid receptor-related osmotically-activated channel (VR-OAC).
Gene name:  TRPV4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 132 6
GENE REF ISO

Function

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Overview 
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.  
4
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • Ortholog Curator
Actin filament bindingdefinition[GO:0051015]  
1
  • Ortholog Curator
Alpha-tubulin bindingdefinition[GO:0043014]  
1
  • Ortholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Beta-tubulin bindingdefinition[GO:0048487]  
1
  • Ortholog Curator
Calcium channel activitydefinition[GO:0005262]  
1
  • UniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • UniProtKB
Microtubule bindingdefinition[GO:0008017]  
1
  • Ortholog Curator
Osmosensor activitydefinition[GO:0005034] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Protein kinase C bindingdefinition[GO:0005080]  
1
  • Ortholog Curator
SH2 domain bindingdefinition[GO:0042169]  
1
  • Ortholog Curator
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • Ortholog Curator
Actin filament organizationdefinition[GO:0007015]  
1
  • Ortholog Curator
Calcium ion importdefinition[GO:0070509]  
1
  • Ortholog Curator
Calcium ion transportdefinition[GO:0006816]  
2
  • UniProtKB
Cell volume homeostasisdefinition[GO:0006884]  
1
  • UniProtKB
Cell-cell junction assemblydefinition[GO:0007043]  
1
  • Ortholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • UniProtKB
Cellular hypotonic responsedefinition[GO:0071476]  
1
  • Ortholog Curator
Cellular response to heatdefinition[GO:0034605]  
1
  • Ortholog Curator
Cellular response to osmotic stressdefinition[GO:0071470]  
1
  • Ortholog Curator
Cortical microtubule organizationdefinition[GO:0043622]  
1
  • Ortholog Curator
Hyperosmotic salinity responsedefinition[GO:0042538] silver  
1
  • Ortholog Compara
Microtubule polymerizationdefinition[GO:0046785]  
1
  • Ortholog Curator
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • Ortholog Curator
Osmosensory signaling pathwaydefinition[GO:0007231]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • UniProtKB
Positive regulation of microtubule depolymerizationdefinition[GO:0031117]  
1
  • Ortholog Curator
Regulation of response to osmotic stressdefinition[GO:0047484] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612]  
1
  • UniProtKB
Vasopressin secretiondefinition[GO:0030103] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPV4
GenomeRNAi: 59341
PRO: PR:Q9HBA0
Chemistry
GuidetoPHARMACOLOGY: 510