TRPV4 - Transient receptor potential cation channel subfamily V member 4 - human protein (Function)
 
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References

 
TRPV4 »  Transient receptor potential cation channel subfamily V member 4  (TrpV4)
 
Protein also known as:  Vanilloid receptor-related osmotically-activated channel (VR-OAC).
Gene name:  TRPV4
Entry whose protein(s) existence is based on evidence at protein level
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1 126 6
GENE REF ISO

Function

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Overview 
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.  
3
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • ISSOrtholog Curator
Actin filament bindingdefinition[GO:0051015]  
  • ISSOrtholog Curator
Alpha-tubulin bindingdefinition[GO:0043014]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Beta-tubulin bindingdefinition[GO:0048487]  
  • ISSOrtholog Curator
Calcium channel activitydefinition[GO:0005262]  
1
  • IDAUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • IMPUniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • IDAUniProtKB
Microtubule bindingdefinition[GO:0008017]  
  • ISSOrtholog Curator
Osmosensor activitydefinition[GO:0005034] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Protein kinase C bindingdefinition[GO:0005080]  
  • ISSOrtholog Curator
SH2 domain bindingdefinition[GO:0042169]  
  • ISSOrtholog Curator
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
  • ISSOrtholog Curator
Actin filament organizationdefinition[GO:0007015]  
  • ISSOrtholog Curator
Calcium ion importdefinition[GO:0070509]  
  • ISSOrtholog Curator
Calcium ion transportdefinition[GO:0006816]  
2
  • IDAUniProtKB
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cell volume homeostasisdefinition[GO:0006884]  
1
  • TASUniProtKB
Cell-cell junction assemblydefinition[GO:0007043]  
  • ISSOrtholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IDAUniProtKB
Cellular hypotonic responsedefinition[GO:0071476]  
  • ISSOrtholog Curator
Cellular response to heatdefinition[GO:0034605]  
  • ISSOrtholog Curator
Cellular response to osmotic stressdefinition[GO:0071470]  
  • ISSOrtholog Curator
Cortical microtubule organizationdefinition[GO:0043622]  
  • ISSOrtholog Curator
Hyperosmotic salinity responsedefinition[GO:0042538] silver  
  • IEAOrtholog Compara
Microtubule polymerizationdefinition[GO:0046785]  
  • ISSOrtholog Curator
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
  • ISSOrtholog Curator
Osmosensory signaling pathwaydefinition[GO:0007231]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Positive regulation of microtubule depolymerizationdefinition[GO:0031117]  
  • ISSOrtholog Curator
Regulation of response to osmotic stressdefinition[GO:0047484] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612]  
1
  • TASUniProtKB
Vasopressin secretiondefinition[GO:0030103] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPV4
GenomeRNAi: 59341
PRO: PR:Q9HBA0
Chemistry
GuidetoPHARMACOLOGY: 510