IL21 - Interleukin-21 - human protein (Function)
 
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IL21 »  Interleukin-21  (IL-21)
 
Protein also known as:  Za11.
Gene name:  IL21
Family name: IL-15/IL-21
Entry whose protein(s) existence is based on evidence at protein level
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1 170 2
GENE REF ISO

Function

 show evidences
Overview 
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.  
2
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Cytokine receptor bindingdefinition[GO:0005126]  
1
  • TASUniProtKB
Interleukin-2 receptor bindingdefinition[GO:0005134]  
1
  • IPIUniProtKB
GO biological process 
Cell maturationdefinition[GO:0048469]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • IDAMGI
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAMGI
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interferon-gamma biosynthetic processdefinition[GO:0045078]  
1
  • NASUniProtKB
Positive regulation of interleukin-10 productiondefinition[GO:0032733] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
1
  • IDABHF-UCL
Positive regulation of natural killer cell cytokine productiondefinition[GO:0002729] silver  
  • IEAOrtholog Compara
Positive regulation of natural killer cell differentiationdefinition[GO:0032825] silver  
  • IEAOrtholog Compara
Positive regulation of natural killer cell mediated cytotoxicitydefinition[GO:0045954] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102]  
2
  • IDAMGI
  • IDAUniProtKB
Positive regulation of tissue remodelingdefinition[GO:0034105]  
1
  • ICBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042511]  
1
  • IDAMGI
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IDAMGI
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+59067  
Jak-STAT signaling pathway  hsa04630+59067  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_21
GenomeRNAi: 59067
PRO: PR:Q9HBE4