ATP6V0A4 - V-type proton ATPase 116 kDa subunit a isoform 4 - human protein (Function)
 
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ATP6V0A4 »  V-type proton ATPase 116 kDa subunit a isoform 4  (V-ATPase 116 kDa isoform a4)
 
Protein also known as:  Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform.
Gene name:  ATP6V0A4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 1
GENE REF ISO

Function

 show evidences
Overview 
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
1
  • IPIUniProtKB
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIHGNC
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • IMPHGNC
Ossificationdefinition[GO:0001503]  
1
  • IMPHGNC
Proton transportdefinition[GO:0015992]  
1
  • IMPHGNC
Regulation of pHdefinition[GO:0006885]  
1
  • IMPHGNC
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+50617  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+50617  
Lysosome  hsa04142+50617  
Metabolic pathways  hsa01100+50617  
Oxidative phosphorylation  hsa00190+50617  
Phagosome  hsa04145+50617  
Rheumatoid arthritis  hsa05323+50617  
Synaptic vesicle cycle  hsa04721+50617  
Tuberculosis  hsa05152+50617  
Vibrio cholerae infection  hsa05110+50617  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V0A4
GenomeRNAi: 50617
PRO: PR:Q9HBG4