BEX1 - Protein BEX1 - human protein (Function)
 
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BEX1 »  Protein BEX1
 
Protein also known as:  Brain-expressed X-linked protein 1.
Gene name:  BEX1
Family name: BEX
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 17 1
GENE REF ISO

Function

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Overview 
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Caution 
Was named BEX2 by some authors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BEX1
GenomeRNAi: 55859
PRO: PR:Q9HBH7