MKNK2 - MAP kinase-interacting serine/threonine-protein kinase 2 - human protein (Function)
 
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MKNK2 »  MAP kinase-interacting serine/threonine-protein kinase 2   [ EC 2.7.11.1 ]
 
Protein also known as:  MAP kinase signal-integrating kinase 2 (Mnk2).
Gene name:  MKNK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus.  
9
  • CuratedUniProtKB
Isoform  Iso 1   Displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.  
9
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular response to arsenic-containing substancedefinition[GO:0071243]  
1
  • IDAUniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactors
Magnesium.  
1
  • CuratedUniProtKB
Binds 1 zinc ion per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedback regulatory manner in response to chemotherapy (e.g. Cytarabine) and thus impairs the generation of antileukemic responses.  
6
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+2872  
MAPK signaling pathway  hsa04010+2872  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Translation regulation  definition   [KW-0810]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MKNK2
GenomeRNAi: 2872
PRO: PR:Q9HBH9
Chemistry
GuidetoPHARMACOLOGY: 2105