AS3MT - Arsenite methyltransferase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AS3MT »  Arsenite methyltransferase   [ EC 2.1.1.137 ]
 
Protein also known as:  S-adenosyl-L-methionine:arsenic(III) methyltransferase.
Gene name:  AS3MT
Family name: Methyltransferase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Arsenite methyltransferase activitydefinition[GO:0030791]  
  • ISSOrtholog Curator
Methylarsonite methyltransferase activitydefinition[GO:0030792]  
  • ISSOrtholog Curator
GO biological process 
Arsonoacetate metabolic processdefinition[GO:0018872]  
  • ISSOrtholog Curator
Methylationdefinition[GO:0032259]  
  • IEAUniProtKB KW
Toxin metabolic processdefinition[GO:0009404]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
S-adenosyl-L-methionine + arsenite S-adenosyl-L-homocysteine + methylarsonate.  
  • CuratedUniProtKB
S-adenosyl-L-methionine + methylarsonite S-adenosyl-L-homocysteine + dimethylarsinate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 11.8 uM for AdoMet
KM 4.6 uM for sodium arsenite

Keywords

Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9HBK9
Other
GeneWiki: AS3MT
GenomeRNAi: 57412
PRO: PR:Q9HBK9