LPAR2 - Lysophosphatidic acid receptor 2 - human protein (Function)
 
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LPAR2 »  Lysophosphatidic acid receptor 2  (LPA-2)
 
Protein also known as:  Lysophosphatidic acid receptor Edg-4.
Gene name:  LPAR2
Entry whose protein(s) existence is based on evidence at protein level
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1 48 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.  
2
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Lipid bindingdefinition[GO:0008289]  
1
  • TASPINC
Lysophosphatidic acid receptor activitydefinition[GO:0070915] silver  
  • IEAInterPro 2 GO
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of Rho protein signal transductiondefinition[GO:0035025] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+9170  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
Lysosphingolipid and LPA receptors  REACT_18365  
Note 
PubMed9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LPAR2
GenomeRNAi: 9170
PRO: PR:Q9HBW0
Chemistry
GuidetoPHARMACOLOGY: 273