LGR6 - Leucine-rich repeat-containing G-protein coupled receptor 6 - human protein (Function)
 
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LGR6 »  Leucine-rich repeat-containing G-protein coupled receptor 6
 
Gene name:  LGR6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.  
2
  • CuratedUniProtKB
GO molecular function 
Not  G-protein coupled receptor activitydefinition[GO:0004930]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
  • ISSOrtholog Curator
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IDAUniProtKB
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_200716  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LGR6
GenomeRNAi: 59352
PRO: PR:Q9HBX8
Chemistry
GuidetoPHARMACOLOGY: 149