NOX3 - NADPH oxidase 3 - human protein (Function)
 
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NOX3 »  NADPH oxidase 3   [ EC 1.6.3.- ]
 
Protein also known as:  Mitogenic oxidase 2 (MOX-2).
Gene name:  NOX3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.4  
GO molecular function 
Superoxide-generating NADPH oxidase activitydefinition[GO:0016175] silver  
  • IEAOrtholog Compara
GO biological process 
Detection of gravitydefinition[GO:0009590] silver  
  • IEAOrtholog Compara
Otolith developmentdefinition[GO:0048840] silver  
  • IEAOrtholog Compara
Superoxide anion generationdefinition[GO:0042554] silver  
  • IEAOrtholog Compara
Temperature homeostasisdefinition[GO:0001659] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride.  
2
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 5960 [ HsNOx03 ]
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leukocyte transendothelial migration  hsa04670+50508  
Osteoclast differentiation  hsa04380+50508  
Phagosome  hsa04145+50508  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOX3
GenomeRNAi: 50508
PRO: PR:Q9HBY0