SGK2 - Serine/threonine-protein kinase Sgk2 - human protein (Function)
 
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SGK2 »  Serine/threonine-protein kinase Sgk2   [ EC 2.7.11.1 ]
 
Protein also known as:  Serum/glucocorticoid-regulated kinase 2.
Gene name:  SGK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Sodium channel regulator activitydefinition[GO:0017080]  
2
  • TASUniProtKB
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Positive regulation of transporter activitydefinition[GO:0032411]  
1
  • TASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • NASUniProtKB
Regulation of cell growthdefinition[GO:0001558]  
1
  • TASUniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • TASUniProtKB
Response to oxidative stressdefinition[GO:0006979]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Caution 
Not regulated by serum or glucocorticoids.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SGK2
GenomeRNAi: 10110
PRO: PR:Q9HBY8
Chemistry
GuidetoPHARMACOLOGY: 1535