ARNT2 - Aryl hydrocarbon receptor nuclear translocator 2 - human protein (Function)
 
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Protein
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ARNT2 »  Aryl hydrocarbon receptor nuclear translocator 2  (ARNT protein 2)
 
Protein also known as:  Class E basic helix-loop-helix protein 1 (bHLHe1).
Gene name:  ARNT2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 2
GENE REF ISO

Function

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Overview 
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed24022475). Specifically recognizes the xenobiotic response element (XRE).  
2
  • UniProtKB
GO molecular function 
Aryl hydrocarbon receptor bindingdefinition[GO:0017162]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • UniProtKB
  • Ortholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • Ortholog Curator
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
GO biological process 
Brain developmentdefinition[GO:0007420]  
1
  • UniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • MGI
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pathways in cancer  hsa05200+9915  
Renal cell carcinoma  hsa05211+9915  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARNT2
GenomeRNAi: 9915
PRO: PR:Q9HBZ2