NOD2 - Nucleotide-binding oligomerization domain-containing protein 2 - human protein (Function)
 
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NOD2 »  Nucleotide-binding oligomerization domain-containing protein 2
 
Protein also known as:  Caspase recruitment domain-containing protein 15.
Gene name:  NOD2
Entry whose protein(s) existence is based on evidence at protein level
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1 341 3
GENE REF ISO

Function

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Overview 
Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
CARD domain bindingdefinition[GO:0050700]  
1
  • IPIUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Muramyl dipeptide bindingdefinition[GO:0032500]  
1
  • IDAHGNC
Peptidoglycan bindingdefinition[GO:0042834]  
1
  • IDAHGNC
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
GO biological process 
Activation of MAPK activity involved in innate immune responsedefinition[GO:0035419]  
  • ISSOrtholog Curator
Cellular response to muramyl dipeptidedefinition[GO:0071225]  
1
  • IDAUniProtKB
Cellular response to peptidoglycandefinition[GO:0071224] silver  
  • IEAOrtholog Compara
Cytokine production involved in immune responsedefinition[GO:0002367]  
1
  • IMPUniProtKB
Defense responsedefinition[GO:0006952]  
1
  • TASHGNC
Defense response to bacteriumdefinition[GO:0042742]  
1
  • IDAHGNC
Defense response to Gram-positive bacteriumdefinition[GO:0050830] silver  
  • IEAOrtholog Compara
Detection of bacteriumdefinition[GO:0016045]  
1
  • IDAHGNC
Detection of biotic stimulusdefinition[GO:0009595]  
1
  • TASHGNC
Detection of muramyl dipeptidedefinition[GO:0032498]  
2
  • IDAHGNC
  • IDAMGI
Immunoglobulin production involved in immunoglobulin mediated immune responsedefinition[GO:0002381] silver  
  • IEAOrtholog Compara
Innate immune responsedefinition[GO:0045087]  
2
  • IDAUniProtKB
Innate immune response in mucosadefinition[GO:0002227] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAHGNC
Macrophage inflammatory protein-1 alpha productiondefinition[GO:0071608] silver  
  • IEAOrtholog Compara
Maintenance of gastrointestinal epitheliumdefinition[GO:0030277]  
1
  • IMPUniProtKB
Microglial cell activation involved in immune responsedefinition[GO:0002282] silver  
  • IEAOrtholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory response to antigenic stimulusdefinition[GO:0002862] silver  
  • IEAOrtholog Compara
Negative regulation of interferon-gamma productiondefinition[GO:0032689] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-12 productiondefinition[GO:0032695] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-18 productiondefinition[GO:0032701] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-2 productiondefinition[GO:0032703] silver  
  • IEAOrtholog Compara
Negative regulation of macrophage apoptotic processdefinition[GO:2000110]  
  • ISSOrtholog Curator
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088] silver  
  • IEAOrtholog Compara
Negative regulation of T cell mediated immunitydefinition[GO:0002710] silver  
  • IEAOrtholog Compara
Negative regulation of toll-like receptor 2 signaling pathwaydefinition[GO:0034136] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720] silver  
  • IEAOrtholog Compara
Nucleotide-binding oligomerization domain containing 2 signaling pathwaydefinition[GO:0070431]  
2
  • IDAUniProtKB
  • IDAMGI
Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responsedefinition[GO:0052033] silver  
  • IEAOrtholog Compara
Positive regulation of B cell activationdefinition[GO:0050871]  
1
  • IDABHF-UCL
Positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriadefinition[GO:0006965] silver  
  • IEAOrtholog Compara
Positive regulation of dendritic cell antigen processing and presentationdefinition[GO:0002606]  
  • ISSOrtholog Curator
Positive regulation of dendritic cell cytokine productiondefinition[GO:0002732] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
  • ISSOrtholog Curator
Positive regulation of gamma-delta T cell activationdefinition[GO:0046645]  
  • ISSOrtholog Curator
Positive regulation of humoral immune response mediated by circulating immunoglobulindefinition[GO:0002925] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
2
  • IDAMGI
  • IDAUniProtKB
Positive regulation of interleukin-1 beta productiondefinition[GO:0032731]  
1
  • IMPBHF-UCL
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718]  
1
  • IDAHGNC
Positive regulation of interleukin-10 productiondefinition[GO:0032733]  
  • ISSOrtholog Curator
Positive regulation of interleukin-12 productiondefinition[GO:0032735] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
1
  • IMPUniProtKB
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IDABHF-UCL
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IDAMGI
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
3
  • IDAUniProtKB
  • IDAMGI
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
  • ISSOrtholog Curator
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
  • ISSOrtholog Curator
Positive regulation of oxidoreductase activitydefinition[GO:0051353]  
  • ISSOrtholog Curator
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
  • ISSOrtholog Curator
Positive regulation of prostaglandin-E synthase activitydefinition[GO:2000363]  
  • ISSOrtholog Curator
Positive regulation of prostaglandin-endoperoxide synthase activitydefinition[GO:0060585]  
  • ISSOrtholog Curator
Positive regulation of stress-activated MAPK cascadedefinition[GO:0032874]  
1
  • IDAMGI
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
2
  • IMPBHF-UCL
  • IDAMGI
Positive regulation of type 2 immune responsedefinition[GO:0002830]  
1
  • IMPBHF-UCL
Protein oligomerizationdefinition[GO:0051259]  
1
  • TASHGNC
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • ICBHF-UCL
Regulation of neutrophil chemotaxisdefinition[GO:0090022] silver  
  • IEAOrtholog Compara
Response to exogenous dsRNAdefinition[GO:0043330] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to muramyl dipeptidedefinition[GO:0032495]  
2
  • IDABHF-UCL
  • IDAHGNC
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
NOD-like receptor signaling pathway  hsa04621+64127  
Shigellosis  hsa05131+64127  
Tuberculosis  hsa05152+64127  
According to Reactome, this protein belongs to the following pathways:
activated TAK1 mediates p38 MAPK activation  REACT_21399  
Interleukin-1 signaling  REACT_22442  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  REACT_21368  
NOD1/2 Signaling Pathway  REACT_75776  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  REACT_21281  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NOD2
GenomeRNAi: 64127
PRO: PR:Q9HC29
Chemistry
GuidetoPHARMACOLOGY: 1763