CAPN10 - Calpain-10 - human protein (Function)
 
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CAPN10 »  Calpain-10   [ EC 3.4.22.- ]
 
Protein also known as:  Calcium-activated neutral proteinase 10 (CANP 10).
Gene name:  CAPN10
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198]  
1
  • IMPBHF-UCL
Cytoskeletal protein bindingdefinition[GO:0008092]  
  • ISSOrtholog Curator
SNARE bindingdefinition[GO:0000149]  
  • ISSOrtholog Curator
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • ISSBHF-UCL
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • IMPBHF-UCL
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • IDABHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • IMPBHF-UCL
Positive regulation of insulin secretiondefinition[GO:0032024]  
1
  • IMPBHF-UCL
Positive regulation of intracellular transportdefinition[GO:0032388]  
1
  • ISSBHF-UCL
Positive regulation of type B pancreatic cell apoptotic processdefinition[GO:2000676] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IMPBHF-UCL
Type B pancreatic cell apoptotic processdefinition[GO:0097050]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.-: Broad endopeptidase specificity.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CAPN10
GenomeRNAi: 11132
PRO: PR:Q9HC96