NEK6 - Serine/threonine-protein kinase Nek6 - human protein (Function)
 
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NEK6 »  Serine/threonine-protein kinase Nek6   [ EC 2.7.11.1 ]
 
Protein also known as:  Never in mitosis A-related kinase 6 (NimA-related protein kinase 6).
Gene name:  NEK6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Kinesin bindingdefinition[GO:0019894]  
1
  • IPIUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
3
  • IDAUniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Chromosome segregationdefinition[GO:0007059]  
1
  • IDAUniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • TASUniProtKB
G2 DNA damage checkpointdefinition[GO:0031572]  
1
  • IMPUniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDAUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
2
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of cellular senescencedefinition[GO:2000772]  
1
  • TASUniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • TASUniProtKB
Regulation of mitotic metaphase/anaphase transitiondefinition[GO:0030071]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IMPGOC
Spindle assemblydefinition[GO:0051225]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of NIMA Kinases NEK9, NEK6, NEK7  REACT_160122  
Nuclear Pore Complex (NPC) Disassembly  REACT_163931  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Chromosome partition  definition   [KW-0159]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NEK6
GenomeRNAi: 10783
PRO: PR:Q9HC98
Chemistry
GuidetoPHARMACOLOGY: 2121