GDPD2 - Glycerophosphoinositol inositolphosphodiesterase GDPD2 - human protein (Function)
 
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GDPD2 »  Glycerophosphoinositol inositolphosphodiesterase GDPD2   [ EC 3.1.4.43 ]
 
Protein also known as:  Glycerophosphodiester phosphodiesterase domain-containing protein 2.
Gene name:  GDPD2
Entry whose protein(s) existence is based on evidence at protein level
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1 13 3
GENE REF ISO

Function

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Overview 
Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Glycerophosphodiester phosphodiesterase activitydefinition[GO:0008889] silver  
  • IEAInterPro 2 GO
Glycerophosphoinositol inositolphosphodiesterase activitydefinition[GO:0047394]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Glycerol metabolic processdefinition[GO:0006071] silver  
  • IEAInterPro 2 GO
Lipid metabolic processdefinition[GO:0006629] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.43: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O glycerol + 1D-myo-inositol 1-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
  • CuratedUniProtKB
 
More information is available from:
Caution 
The catalytic domain of GDPD2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54857
PRO: PR:Q9HCC8