GP6 - Platelet glycoprotein VI - human protein (Function)
 
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GP6 »  Platelet glycoprotein VI  (GPVI)
 
Protein also known as:  Glycoprotein 6.
Gene name:  GP6
Entry whose protein(s) existence is based on evidence at protein level
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1 135 3
GENE REF ISO

Function

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Overview 
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.  
1
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Receptor activitydefinition[GO:0004872]  
1
  • TASUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Enzyme linked receptor protein signaling pathwaydefinition[GO:0007167]  
1
  • TASPINC
Platelet activationdefinition[GO:0030168]  
1
  • NASUniProtKB
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
ECM-receptor interaction  hsa04512+51206  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPVI
GenomeRNAi: 51206
PRO: PR:Q9HCN6