CYP4F12 - Cytochrome P450 4F12 - human protein (Function)
 
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Protein
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CYP4F12 »  Cytochrome P450 4F12
 
Protein also known as:  CYPIVF12.
Gene name:  CYP4F12
Family name: Cytochrome P450
This protein has been shown to exist at protein level
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1 11 1
GENE REF ISO

Function

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Overview 
Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.  
  • CuratedUniProtKB
GO molecular function 
Alkane 1-monooxygenase activitydefinition[GO:0018685]  
  • ISSOrtholog Curator
Arachidonic acid epoxygenase activitydefinition[GO:0008392]  
  • ISSOrtholog Curator
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Electron carrier activitydefinition[GO:0009055] silver  
  • IEAInterPro 2 GO
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Leukotriene-B4 20-monooxygenase activitydefinition[GO:0050051]  
  • ISSOrtholog Curator
Vitamin-K-epoxide reductase (warfarin-sensitive) activitydefinition[GO:0047057]  
  • ISSOrtholog Curator
GO biological process 
Arachidonic acid metabolic processdefinition[GO:0019369]  
  • ISSOrtholog Curator
Drug metabolic processdefinition[GO:0017144]  
  • ISSOrtholog Curator
Epoxygenase P450 pathwaydefinition[GO:0019373]  
  • ISSOrtholog Curator
Leukotriene B4 catabolic processdefinition[GO:0036101]  
  • ISSOrtholog Curator
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
  • ISSOrtholog Curator
Negative regulation of blood coagulationdefinition[GO:0030195]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • ISSOrtholog Curator
Pressure natriuresisdefinition[GO:0003095]  
  • ISSOrtholog Curator
Renal water homeostasisdefinition[GO:0003091]  
  • ISSOrtholog Curator
Sodium ion homeostasisdefinition[GO:0055078]  
  • ISSOrtholog Curator
Very long-chain fatty acid metabolic processdefinition[GO:0000038]  
  • ISSOrtholog Curator
Vitamin E metabolic processdefinition[GO:0042360]  
  • ISSOrtholog Curator
Vitamin K biosynthetic processdefinition[GO:0042371]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]