PREB - Prolactin regulatory element-binding protein - human protein (Function)
 
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PREB »  Prolactin regulatory element-binding protein
 
Protein also known as:  Mammalian guanine nucleotide exchange factor mSec12.
Gene name:  PREB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
GO biological process 
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+10113  
According to Reactome, this protein belongs to the following pathways:
Membrane Trafficking  REACT_11123  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
ER-Golgi transport  definition   [KW-0931]
Protein transport  definition   [KW-0653]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Transport  definition   [KW-0813]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PREB
GenomeRNAi: 10113
PRO: PR:Q9HCU5