TRPC7 - Short transient receptor potential channel 7 - human protein (Function)
 
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TRPC7 »  Short transient receptor potential channel 7  (TrpC7)
 
Protein also known as:  Transient receptor protein 7 (TRP-7).
Gene name:  TRPC7
Entry whose protein(s) existence is based on evidence at protein level
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1 27 3
GENE REF ISO

Function

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Overview 
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.  
  • CuratedUniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Manganese ion transportdefinition[GO:0006828] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Effects of PIP2 hydrolysis  REACT_2202  
Elevation of cytosolic Ca2+ levels  REACT_162  
Role of second messengers in netrin-1 signaling  REACT_22228  
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPC7
GenomeRNAi: 57113
PRO: PR:Q9HCX4
Chemistry
GuidetoPHARMACOLOGY: 492