TXNRD2 - Thioredoxin reductase 2, mitochondrial - human protein (Function)
 
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References

 
TXNRD2 »  Thioredoxin reductase 2, mitochondrial   [ EC 1.8.1.9 ]
 
Protein also known as:  Thioredoxin reductase TR3.
Gene name:  TXNRD2
Entry whose protein(s) existence is based on evidence at protein level
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1 42 4
GENE REF ISO

Function

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Overview 
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.  
  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
NADP bindingdefinition[GO:0050661] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Thioredoxin-disulfide reductase activitydefinition[GO:0004791]  
  • ISSOrtholog Curator
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Response to oxygen radicaldefinition[GO:0000305]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.8.1.9: Thioredoxin + NADP(+) thioredoxin disulfide + NADPH.  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pyrimidine metabolism  hsa00240+10587  
Selenocompound metabolism  hsa00450+10587  
According to Reactome, this protein belongs to the following pathway:
Cellular responses to stress  REACT_120956  
Note 
The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10587
PRO: PR:Q9NNW7