CD209 - CD209 antigen - human protein (Function)
 
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CD209 »  CD209 antigen
 
Protein also known as:  Dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN); CD antigen CD209.
Gene name:  CD209
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.  
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  • UniProtKB
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.  
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  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
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  • UniProtKB
Mannose bindingdefinition[GO:0005537]  
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  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Peptide antigen bindingdefinition[GO:0042605]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Virion bindingdefinition[GO:0046790]  
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  • UniProtKB
GO biological process 
Antigen processing and presentationdefinition[GO:0019882]  
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  • UniProtKB
Cell-cell recognitiondefinition[GO:0009988]  
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  • UniProtKB
Endocytosisdefinition[GO:0006897]  
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  • UniProtKB KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesdefinition[GO:0007157]  
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  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
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  • UniProtKB
Intracellular transport of virusdefinition[GO:0075733]  
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  • UniProtKB
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
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  • UniProtKB
Modulation by virus of host morphology or physiologydefinition[GO:0019048]  
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  • UniProtKB
Peptide antigen transportdefinition[GO:0046968]  
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  • UniProtKB
Regulation of T cell proliferationdefinition[GO:0042129]  
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  • MGI
Viral genome replicationdefinition[GO:0019079]  
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  • UniProtKB
Virion attachment to host celldefinition[GO:0019062]  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Measles  hsa05162+30835  
Phagosome  hsa04145+30835  
Tuberculosis  hsa05152+30835  
Note 
In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during transport by DCs from the periphery to lymphoid organs.  
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  • UniProtKB
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Cell adhesion  definition   [KW-0130]
Endocytosis  definition   [KW-0254]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DC-SIGN
GenomeRNAi: 30835
PRO: PR:Q9NNX6