ABCB6 - ATP-binding cassette sub-family B member 6, mitochondrial - human protein (Function)
 
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Protein
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ABCB6 »  ATP-binding cassette sub-family B member 6, mitochondrial
 
Protein also known as:  Ubiquitously-expressed mammalian ABC half transporter.
Gene name:  ABCB6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.210.6  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAMGI
Efflux transmembrane transporter activitydefinition[GO:0015562]  
1
  • IDAUniProtKB
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Heme-transporting ATPase activitydefinition[GO:0015439]  
1
  • IMPUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IMPGOC
Brain developmentdefinition[GO:0007420]  
1
  • IMPUniProtKB
Cadmium ion transmembrane transportdefinition[GO:0070574] silver  
  • IBARefGenome
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • NASUniProtKB
Detoxification of cadmium iondefinition[GO:0071585] silver  
  • IBARefGenome
Heme transportdefinition[GO:0015886]  
2
  • IDAUniProtKB
Porphyrin-containing compound biosynthetic processdefinition[GO:0006779]  
1
  • IDAUniProtKB
Skin developmentdefinition[GO:0043588]  
1
  • IMPUniProtKB
Transportdefinition[GO:0006810]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+10058  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
Depletion of Abcb6 by RNAi abrogates heme biosynthesis. Overexpression enhances porphyrin biosynthesis.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB6
GenomeRNAi: 10058
PRO: PR:Q9NP58