SLC40A1 - Solute carrier family 40 member 1 - human protein (Function)
 
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SLC40A1 »  Solute carrier family 40 member 1
 
Protein also known as:  Iron-regulated transporter 1.
Gene name:  SLC40A1
Entry whose protein(s) existence is based on evidence at protein level
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1 124 1
GENE REF ISO

Function

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Overview 
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the ferroportin (fpn) family  2.A.100.1.4  
GO molecular function 
Ferrous iron transmembrane transporter activitydefinition[GO:0015093]  
1
  • Ortholog Curator
Iron channel activitydefinition[GO:0097689]  
1
  • Ortholog Curator
Iron ion transmembrane transporter activitydefinition[GO:0005381]  
1
  • BHF-UCL
Peptide hormone bindingdefinition[GO:0017046]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Receptor activitydefinition[GO:0004872]  
1
  • Ortholog Curator
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • BHF-UCL
Endothelium developmentdefinition[GO:0003158] silver  
1
  • Ortholog Compara
Ferrous iron exportdefinition[GO:1903988]  
1
  • Ortholog Curator
Iron ion transmembrane transportdefinition[GO:0034755]  
1
  • BHF-UCL
Lymphocyte homeostasisdefinition[GO:0002260] silver  
1
  • Ortholog Compara
Multicellular organismal iron ion homeostasisdefinition[GO:0060586]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoter in response to irondefinition[GO:0034395] silver  
1
  • Ortholog Compara
Spleen trabecula formationdefinition[GO:0060345] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+30061  
According to Reactome, this protein belongs to the following pathways:
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)  R-HSA-5655799  
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)  R-HSA-5619049  
Iron uptake and transport  R-HSA-917937  
Metal ion SLC transporters  R-HSA-425410  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Ferroportin
GenomeRNAi: 30061
PRO: PR:Q9NP59
Chemistry
GuidetoPHARMACOLOGY: 1194