SLC40A1 - Solute carrier family 40 member 1 - human protein (Function)
 
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Protein
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References

 
SLC40A1 »  Solute carrier family 40 member 1
 
Protein also known as:  Iron-regulated transporter 1.
Gene name:  SLC40A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 109 1
GENE REF ISO

Function

 show evidences
Overview 
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ferroportin (fpn) family  2.A.100.1.4  
GO molecular function 
Iron ion transmembrane transporter activitydefinition[GO:0005381]  
1
  • IMPBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • IMPBHF-UCL
Endothelium developmentdefinition[GO:0003158] silver  
  • IEAOrtholog Compara
Iron ion transmembrane transportdefinition[GO:0034755]  
1
  • IMPBHF-UCL
Lymphocyte homeostasisdefinition[GO:0002260] silver  
  • IEAOrtholog Compara
Multicellular organismal iron ion homeostasisdefinition[GO:0060586] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Spleen trabecula formationdefinition[GO:0060345] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+30061  
According to Reactome, this protein belongs to the following pathways:
Iron uptake and transport  REACT_25060  
Metal ion SLC transporters  REACT_20547  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Ferroportin
GenomeRNAi: 30061
PRO: PR:Q9NP59