ALG13 - Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 - human protein (Function)
 
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ALG13 »  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13   [ EC 3.4.19.12EC 2.4.1.141 ]
 
Protein also known as:  UDP-N-acetylglucosamine transferase subunit ALG13 homolog.
Gene name:  ALG13
Family name: Glycosyltransferase 28
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Cysteine-type peptidase activitydefinition[GO:0008234]  
  • IEAUniProtKB KW
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activitydefinition[GO:0004577]  
  • IEAEC 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
Lipid glycosylationdefinition[GO:0030259] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.141: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.  
  • CuratedUniProtKB
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 1  GT1  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+79868  
N-Glycan biosynthesis  hsa00510+79868  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALG13
GenomeRNAi: 79868
PRO: PR:Q9NP73