ABCB9 - ATP-binding cassette sub-family B member 9 - human protein (Function)
 
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ABCB9 »  ATP-binding cassette sub-family B member 9
 
Protein also known as:  ATP-binding cassette transporter 9 (ABC transporter 9 protein).
Gene name:  ABCB9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.209.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Peptide-transporting ATPase activitydefinition[GO:0015440]  
3
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IPIUniProtKB
Substrate-specific transmembrane transporter activitydefinition[GO:0022891]  
1
  • IDAUniProtKB
GO biological process 
Not  Antigen processing and presentation of peptide antigen via MHC class Idefinition[GO:0002474]  
1
  • IDAUniProtKB
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Peptide transportdefinition[GO:0015833]  
3
  • IDAUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Transmembrane transportdefinition[GO:0055085] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+23457  
Lysosome  hsa04142+23457  
Caution 
Has also been detected in the endoplasmic reticulum (PubMed11011155) but appears to be a lysosomal protein in vivo.  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 6.8 uM for peptide RRYQNSTCL
Dependence
pH Optimum pH is 7.0.
Temperature Optimum temperature is 37 degrees Celsius.

Keywords

Biological process 
Peptide transport  definition   [KW-0571]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB9
GenomeRNAi: 23457
PRO: PR:Q9NP78