KCNMB3 - Calcium-activated potassium channel subunit beta-3 - human protein (Function)
 
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KCNMB3 »  Calcium-activated potassium channel subunit beta-3
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-3.
Gene name:  KCNMB3
Family name: KCNMB (TC 8.A.14.1) » KCNMB3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel.  
2
  • CuratedUniProtKB
Isoform  Iso 4   Induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.  
2
  • CuratedUniProtKB
Isoforms  Iso 2 , Iso 3 and Iso 4   Partially inactivate the current of KCNBMA.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family  8.A.14.1.4  
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • IDAUniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
2
  • NASUniProtKB
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • IDAUniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • IDAUniProtKB
Neuronal action potentialdefinition[GO:0019228]  
1
  • IDAUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+27094  
According to Reactome, this protein belongs to the following pathways:
Ca2+ activated K+ channels  REACT_75896  
cGMP effects  REACT_23767  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB3
GenomeRNAi: 27094
PRO: PR:Q9NPA1