ACKR4 - Atypical chemokine receptor 4 - human protein (Function)
 
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ACKR4 »  Atypical chemokine receptor 4
 
Gene name:  ACKR4
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.  
3
  • CuratedUniProtKB
GO molecular function 
Chemokine bindingdefinition[GO:0019956] silver  
  • IEAInterPro 2 GO
Chemokine receptor activitydefinition[GO:0004950]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Scavenger receptor activitydefinition[GO:0005044] silver  
  • IEAInterPro 2 GO
GO biological process 
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Receptor-mediated endocytosisdefinition[GO:0006898]  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Chemokine receptors bind chemokines  REACT_15344  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCRL1
GenomeRNAi: 51554
PRO: PR:Q9NPB9
Chemistry
GuidetoPHARMACOLOGY: 315