LTB4R2 - Leukotriene B4 receptor 2 - human protein (Function)
 
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Protein
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LTB4R2 »  Leukotriene B4 receptor 2  (LTB4-R2)
 
Protein also known as:  Seven transmembrane receptor BLTR2.
Gene name:  LTB4R2
Entry whose protein(s) existence is based on evidence at protein level
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1 40 2
GENE REF ISO

Function

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Overview 
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.  
  • CuratedUniProtKB
GO molecular function 
Leukotriene receptor activitydefinition[GO:0004974] silver  
  • IEAInterPro 2 GO
GO biological process 
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+56413  
Neuroactive ligand-receptor interaction  hsa04080+56413  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Leukotriene receptors  REACT_18302  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 56413
PRO: PR:Q9NPC1
Chemistry
GuidetoPHARMACOLOGY: 268