KCNK9 - Potassium channel subfamily K member 9 - human protein (Function)
 
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KCNK9 »  Potassium channel subfamily K member 9
 
Protein also known as:  Acid-sensitive potassium channel protein TASK-3.
Gene name:  KCNK9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
PH-dependent, voltage-insensitive, background potassium channel protein.  
3
  • UniProtKB
GO molecular function 
Potassium ion leak channel activitydefinition[GO:0022841]  
1
  • RefGenome
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Voltage-gated ion channel activitydefinition[GO:0005244]  
1
  • UniProtKB KW
GO biological process 
Cochlea developmentdefinition[GO:0090102] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
TWIK-releated acid-sensitive K+ channel (TASK)  REACT_75899  
Note 
Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.  
1
  • UniProtKB
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK9
GenomeRNAi: 51305
PRO: PR:Q9NPC2
Chemistry
GuidetoPHARMACOLOGY: 520