KCNK9 - Potassium channel subfamily K member 9 - human protein (Function)
 
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Protein
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KCNK9 »  Potassium channel subfamily K member 9
 
Protein also known as:  Acid-sensitive potassium channel protein TASK-3.
Gene name:  KCNK9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
PH-dependent, voltage-insensitive, background potassium channel protein.  
2
  • CuratedUniProtKB
GO molecular function 
Potassium channel activitydefinition[GO:0005267]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Voltage-gated ion channel activitydefinition[GO:0005244]  
  • IEAUniProtKB KW
GO biological process 
Cochlea developmentdefinition[GO:0090102] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.  
  • CuratedUniProtKB
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK9
GenomeRNAi: 51305
PRO: PR:Q9NPC2
Chemistry
GuidetoPHARMACOLOGY: 520