CCNB1IP1 - E3 ubiquitin-protein ligase CCNB1IP1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CCNB1IP1 »  E3 ubiquitin-protein ligase CCNB1IP1   [ EC 6.3.2.- ]
 
Protein also known as:  Cyclin-B1-interacting protein 1.
Gene name:  CCNB1IP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 14 1
GENE REF ISO

Function

 show evidences
Overview 
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.  
2
  • CuratedUniProtKB
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.  
2
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Blastocyst formationdefinition[GO:0001825] silver  
  • IEAOrtholog Compara
Chiasma assemblydefinition[GO:0051026]  
  • ISSOrtholog Curator
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Reciprocal meiotic recombinationdefinition[GO:0007131]  
  • ISSOrtholog Curator
Spermatid developmentdefinition[GO:0007286] silver  
  • IEAOrtholog Compara
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Meiosis  definition   [KW-0469]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CCNB1IP1
GenomeRNAi: 57820
PRO: PR:Q9NPC3