A4GALT - Lactosylceramide 4-alpha-galactosyltransferase - human protein (Function)
 
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A4GALT »  Lactosylceramide 4-alpha-galactosyltransferase   [ EC 2.4.1.228 ]
 
Protein also known as:  UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase.
Gene name:  A4GALT
Family name: Glycosyltransferase 32
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.  
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  • UniProtKB
GO molecular function 
Galactosyltransferase activitydefinition[GO:0008378]  
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  • UniProtKB
  • MGI
Lactosylceramide 4-alpha-galactosyltransferase activitydefinition[GO:0050512]  
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  • EC 2 GO
Toxic substance bindingdefinition[GO:0015643] silver  
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  • Ortholog Compara
GO biological process 
Globoside biosynthetic processdefinition[GO:0001576] silver  
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  • Ortholog Compara
Glycosphingolipid biosynthetic processdefinition[GO:0006688]  
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  • UniProtKB
Plasma membrane organizationdefinition[GO:0007009]  
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  • MGI
Protein glycosylationdefinition[GO:0006486]  
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  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.228: UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.  
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  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 32  GT32  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - globo series  hsa00603+53947  
Metabolic pathways  hsa01100+53947  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: A4GALT
GenomeRNAi: 53947
PRO: PR:Q9NPC4